The COMET tool rapidly classifies HIV-1 nucleotide sequences into subtypes. You can submit your sequences either by pasting them in the form (b) or uploading them (a).

1.0smaller HIV-1 recombination detection window (should detect more URF), CRF additions to the training set2014-03-26
0.5new HIV-1 thresholds, should slightly improve the results2012-06-11
0.3additional support for CRF 44_BF - 49_cpx for HIV-12011-12-20
0.1initial version2010-03-27

(a) upload the sequences in fasta format:

I confirm to use COMET only for non-commercial research purpose (*)

(b) paste the sequences in fasta format (try out example):

I confirm to use COMET only for non-commercial research purpose (*)

Privacy police:
The submitted sequences are deleted as soon the results have been generated.
Supplementary information:
HIV-1 training set

If you use COMET, please cite:
Daniel Struck; Glenn Lawyer; Anne-Marie Ternes; Jean-Claude Schmit; Danielle Perez Bercoff. COMET: adaptive context-based modeling for ultrafast HIV-1 subtype identification. Nucleic Acids Research 2014; doi: 10.1093/nar/gku739 (full text)

Publications that used COMET:
Pineda-Peña AC, Faria NR, Imbrechts S, Libin P, Abecasis AB, Deforche K, Gómez-López A, Camacho RJ, de Oliveira T, Vandamme. Automated subtyping of HIV-1 genetic sequences for clinical and surveillance purposes: Performance evaluation of the new REGA version 3 and seven other tools. Infect Genet Evol. 2013 May 7. pii: S1567-1348(13)00181-0. doi: 10.1016/j.meegid.2013.04.032. (full text)

Lessells RJ, Katzenstein DK, de Oliveira T. Are subtype differences important in HIV drug resistance? Curr Opin Virol. 2012 Oct;2(5):636-43. doi: 10.1016/j.coviro.2012.08.006. Epub 2012 Sep 21.

(*) The COMET-HIV and COMET-HCV services provided herein are "For non-commercial research use only". For all commercial uses, please contact our Exclusive Licensee, ABL SA (www.ablsa.com) at comet@ablsa.com.

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